Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase.
نویسندگان
چکیده
Epstein-Barr virus transformed human lymphocytes despite the presence of up to 500 microM acyclovir [9-(2-hydroxyethoxymethyl)guanine], a viral DNA polymerase inhibitor. The transformed cells contained multiple Epstein-Barr virus genome copy numbers. Functional viral DNA polymerase is probably not required for cell transformation and the initial amplification of the viral genome.
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ورودعنوان ژورنال:
- Journal of virology
دوره 53 1 شماره
صفحات -
تاریخ انتشار 1985